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mljgoums 2026, 20(2): 27-30 |
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Asghary A, Saghaeian Jazi M, Mir S M, Doulani A, Joshaghani H R. Association between lipid metabolism markers and gastric cancer stage and grade: A Focus on ApoB. mljgoums 2026; 20 (2) :27-30
URL: http://mlj.goums.ac.ir/article-1-1961-en.html
URL: http://mlj.goums.ac.ir/article-1-1961-en.html
Amir Asghary1 
, Marie Saghaeian Jazi2 , Seyed Mostafa Mir3 , Abbas Doulani4 , Hamid Reza Joshaghani5
, Marie Saghaeian Jazi2 , Seyed Mostafa Mir3 , Abbas Doulani4 , Hamid Reza Joshaghani5
1- Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran; Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4- Department of Information Science, Faculty of Education and Psychology, Alzahra University, Tehran, Iran
5- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,joshaghani@goums.ac.ir
2- Metabolic Disorders Research Center, Biomedical Research Institute, Golestan University of Medical Sciences, Gorgan, Iran
3- Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
4- Department of Information Science, Faculty of Education and Psychology, Alzahra University, Tehran, Iran
5- Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran ,
Abstract: (3679 Views)
Background: Gastric cancer (GC), particularly adenocarcinoma, remains a major global health burden with high mortality, largely because of late-stage diagnosis and the limited availability of reliable biomarkers for disease monitoring. Lipid metabolism plays a crucial role in tumor biology, and serum lipid-related markers, including apolipoproteins, have been proposed as potential non-invasive indicators of tumor progression. This study aimed to evaluate the association between serum lipid profiles and tumor stage and histological grade in patients with gastric adenocarcinoma.
Methods: Fifty patients diagnosed with gastric adenocarcinoma were enrolled. Serum levels of total cholesterol, triglycerides, HDL-C, LDL-C, ApoA1, and ApoB were measured. Patients were categorized into early (Stages I-II) and advanced (Stages III-IV) tumor stages, as well as into moderately differentiated versus poorly differentiated grades. The Shapiro-Wilk test was used to assess data normality. Parametric and non-parametric tests were applied accordingly. A p-value < 0.05 was considered statistically significant.
Results: ApoB was the only parameter showing a significant association with tumor stage. Patients with advanced-stage GC had significantly lower mean ApoB levels than those in early stages (52.4 ± 2.6 vs. 63.4 ± 5.2 mg/dL, p = 0.042). No statistically significant differences were observed in ApoA1, HDL-C, total cholesterol, triglycerides, LDL-C, or VLDL with respect to either tumor stage or histological grade.
Conclusion: ApoB levels appear to decline with advancing tumor stage in gastric adenocarcinoma, suggesting a potential role as a marker for evaluating disease burden. Although no association was found with tumor grade, further validation in larger prospective studies incorporating metabolic and inflammatory covariates is warranted.
Methods: Fifty patients diagnosed with gastric adenocarcinoma were enrolled. Serum levels of total cholesterol, triglycerides, HDL-C, LDL-C, ApoA1, and ApoB were measured. Patients were categorized into early (Stages I-II) and advanced (Stages III-IV) tumor stages, as well as into moderately differentiated versus poorly differentiated grades. The Shapiro-Wilk test was used to assess data normality. Parametric and non-parametric tests were applied accordingly. A p-value < 0.05 was considered statistically significant.
Results: ApoB was the only parameter showing a significant association with tumor stage. Patients with advanced-stage GC had significantly lower mean ApoB levels than those in early stages (52.4 ± 2.6 vs. 63.4 ± 5.2 mg/dL, p = 0.042). No statistically significant differences were observed in ApoA1, HDL-C, total cholesterol, triglycerides, LDL-C, or VLDL with respect to either tumor stage or histological grade.
Conclusion: ApoB levels appear to decline with advancing tumor stage in gastric adenocarcinoma, suggesting a potential role as a marker for evaluating disease burden. Although no association was found with tumor grade, further validation in larger prospective studies incorporating metabolic and inflammatory covariates is warranted.
Keywords: Adenocarcinoma, Stomach, Apolipoproteins B, Lipid Metabolism, Neoplasm Staging, Neoplasm Grading
Research Article: Original Paper |
Subject:
Biochemistry
Received: 2025/07/6 | Accepted: 2025/08/27 | Published: 2026/04/27 | ePublished: 2026/04/27
Received: 2025/07/6 | Accepted: 2025/08/27 | Published: 2026/04/27 | ePublished: 2026/04/27
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