en دیگر Others مرور سیستمی Systematic Review <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><span style="unicode-bidi:embed"><span calibri=""><span bodoni="" class="fontstyle01" condensed="" mt=""><span style="color:black"><span style="font-weight:bold"><span style="font-style:normal"><span style="line-height:200%"><span new="" roman="" times="">Background:</span></span></span></span></span></span><span style="line-height:200%"><span new="" roman="" times=""> Nontuberculous mycobacteria (NTM) are isolated from domestic and animal products as well as man-made systems such as medical devices, drinking water systems, water tanks, and shower streams. &nbsp;This study aimed to investigate the prevalence of NTM in clinical samples in Iran during 2000-2022. </span></span></span></span></span><br> <span style="line-height:200%"><span style="unicode-bidi:embed"><span calibri=""><span bodoni="" class="fontstyle01" condensed="" mt=""><span style="color:black"><span style="font-weight:bold"><span style="font-style:normal"><span style="line-height:200%"><span new="" roman="" times="">Methods:</span></span></span></span></span></span><span style="line-height:200%"><span new="" roman="" times=""> Published studies addressing the prevalence of NTM in clinical samples in Iran were reviewed according to the Preferred Reporting Items for Meta-Analyses and Systematic Reviews protocol. &nbsp;Original articles in Persian and English published between January 2000 and 2022 in databases such as Scopus, PubMed, Web of Science, Google Scholar, and Iranian databases were included. The prevalence of NTM at 95% confidence interval (CI) was calculated by comprehensive meta-analysis.</span></span></span></span></span><br> <span style="line-height:200%"><span style="unicode-bidi:embed"><span calibri=""><span bodoni="" class="fontstyle01" condensed="" mt=""><span style="color:black"><span style="font-weight:bold"><span style="font-style:normal"><span style="line-height:200%"><span new="" roman="" times="">Results:</span></span></span></span></span></span><span style="line-height:200%"><span new="" roman="" times=""> Overall, 26 studies were included in the review. The combined prevalence of NTM in positive mycobacterial<i> </i>cultures was 4.5% (95% Cl: 3.1-6.5). <i>Mycobacterium simiae </i>[35.8% (95% CI 16.4-44.4)], <i>Mycobacterium intracellulare </i>[19% (95% CI 8.7-28.3)], and <i>Mycobacterium kansasii </i>[13.4% (95% CI 7.3-24.3)] were the most common slowly growing species, while <i>Mycobacterium fortuitum </i>[24.6% (95% CI 12.9-46.7)], <i>Mycobacterium terrae</i> [18.5 % (95% CI 11.5-29.2)], and <i>Mycobacterium gastri</i> [15.9% (95% CI6.0-41.2)] were the most prevalent rapidly growing mycobacteria.</span></span></span></span></span></span></span><br> <span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><span style="unicode-bidi:embed"><span bodoni="" class="fontstyle01" condensed="" mt=""><span style="color:black"><span style="font-weight:bold"><span style="font-style:normal"><span style="line-height:200%"><span new="" roman="" times="">Conclusion:</span></span></span></span></span></span><span style="line-height:200%"><span new="" roman="" times="">&nbsp; In summary, our findings indicate a relatively high combined prevalence of NTM in clinical samples in Iran.&nbsp; Some of these species such as <i>M. simiae </i>can have clinical and radiologic manifestations<i> </i>similar to those of TB and are resistant to anti-TB drugs. Therefore, standardizing the use of molecular<i> </i>methods for the detection of NTM seems necessary.<b> </b></span></span></span></span></span></span></div> Nontuberculous Mycobacteria,Mycobacterium abscessus,Meta-Analysis, 22 31 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1210-2&slc_lang=en&sid=1 Fahimeh Firoozeh 100319475328460032001 100319475328460032001 No Department of Microbiology, Islamic Azad University of Damghan, Damghan, Iran Arezoo Firoozeh arez90fir89@yahoo.com 100319475328460032002 100319475328460032002 Yes Mashhad Uni Meed Sci Abbas Salmani salm90ab56@gmail.com 100319475328460032003 100319475328460032003 No Gerash Uni Med Sci